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Yoshiki Sawa Selected Research

Hypoxia (Hypoxemia)

1/2021Innovative therapeutic strategy using prostaglandin I2 agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension.
1/2021Human induced pluripotent stem cell-derived three-dimensional cardiomyocyte tissues ameliorate the rat ischemic myocardium by remodeling the extracellular matrix and cardiac protein phenotype.
1/2020Laminin-221 Enhances Therapeutic Effects of Human-Induced Pluripotent Stem Cell-Derived 3-Dimensional Engineered Cardiac Tissue Transplantation in a Rat Ischemic Cardiomyopathy Model.
9/2016Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model.
5/2015Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.
3/2010Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology.
9/2008Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells.

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Yoshiki Sawa Research Topics

Disease

115Heart Failure
04/2024 - 02/2002
55Cardiomyopathies (Cardiomyopathy)
01/2023 - 11/2002
52Myocardial Infarction
03/2024 - 03/2002
38Fibrosis (Cirrhosis)
01/2023 - 11/2002
25Mitral Valve Insufficiency (Mitral Regurgitation)
12/2023 - 12/2008
25Aortic Valve Stenosis (Aortic Stenosis)
01/2023 - 09/2009
25Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
01/2022 - 05/2005
23Ischemia
02/2024 - 03/2003
21Infarction (Infarctions)
04/2022 - 12/2002
19Infections
12/2021 - 01/2003
16Stroke (Strokes)
07/2023 - 11/2002
16Neoplasms (Cancer)
02/2022 - 01/2006
12Inflammation (Inflammations)
10/2022 - 11/2002
11Hypertrophy
10/2022 - 12/2004
11Myocardial Ischemia (Ischemic Heart Diseases)
01/2021 - 09/2002
11Reperfusion Injury
06/2019 - 09/2002
10Hemorrhage
02/2024 - 02/2011
10Pulmonary Hypertension
02/2022 - 05/2002
9Aortic Dissection
05/2023 - 02/2004
9Aneurysm (Aneurysms)
05/2023 - 06/2008
9Atrial Fibrillation
12/2021 - 04/2010
9Endoleak
11/2021 - 07/2009
9Left Ventricular Dysfunction
10/2021 - 09/2005
8Wounds and Injuries (Trauma)
10/2022 - 01/2012
8Endocarditis
01/2021 - 02/2004
7Cardiac Arrhythmias (Arrythmia)
02/2024 - 01/2010
7Peripheral Arterial Disease
01/2023 - 09/2002
7Hypoxia (Hypoxemia)
01/2021 - 09/2008
7Coronary Artery Disease (Coronary Atherosclerosis)
10/2020 - 02/2004
7Ventricular Remodeling
11/2017 - 09/2011
6Cardiogenic Shock
12/2023 - 02/2006
6Rupture
01/2022 - 08/2011
6Chronic Limb-Threatening Ischemia
09/2021 - 08/2004
6Cerebral Infarction
12/2019 - 02/2004
5Thrombosis (Thrombus)
12/2023 - 09/2004
5Aortic Aneurysm (Aneurysm, Aortic)
12/2022 - 08/2010
5Diabetes Mellitus
11/2022 - 01/2016
5Congenital Heart Defects (Congenital Heart Defect)
06/2021 - 10/2016
5Pathologic Constriction (Stenosis)
12/2020 - 07/2005
5Heart Diseases (Heart Disease)
01/2019 - 04/2008
5Lung Injury
01/2019 - 12/2004
5Acute Kidney Injury (Acute Renal Failure)
01/2018 - 09/2010
5Liver Diseases (Liver Disease)
12/2013 - 01/2005
5Spinal Cord Ischemia
06/2008 - 10/2004
4Myocarditis (Carditis)
11/2023 - 01/2009
4Aortic Arch Aneurysm
05/2023 - 10/2002
4Tachycardia (Tachyarrhythmias)
01/2022 - 04/2010
4False Aneurysm (Pseudoaneurysm)
01/2021 - 08/2011
4Thymoma (Thymic Carcinoma)
10/2020 - 04/2008
4Lung Neoplasms (Lung Cancer)
06/2019 - 08/2007
4Emphysema
01/2019 - 03/2005

Drug/Important Bio-Agent (IBA)

22Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
04/2022 - 05/2002
21CytokinesIBA
03/2024 - 02/2002
17Therapeutic UsesIBA
01/2023 - 04/2008
17Epoprostenol (Prostacyclin)FDA LinkGeneric
01/2023 - 05/2002
11salicylhydroxamic acid (SHAM)IBA
01/2023 - 08/2009
9CollagenIBA
10/2023 - 11/2004
9Indicators and Reagents (Reagents)IBA
01/2022 - 12/2004
9Proteins (Proteins, Gene)FDA Link
01/2022 - 03/2005
7ONO 1301IBA
01/2023 - 01/2013
7ameroidIBA
12/2021 - 11/2011
7Peptides (Polypeptides)IBA
01/2018 - 11/2003
6Biomarkers (Surrogate Marker)IBA
02/2016 - 01/2013
6Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2005 - 08/2004
5Brain Natriuretic Peptide (Natrecor)FDA Link
01/2023 - 03/2014
5CalciumIBA
10/2022 - 03/2005
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2020 - 03/2011
5SteroidsIBA
06/2018 - 07/2009
4Cytoskeletal ProteinsIBA
12/2021 - 08/2005
4Insulin (Novolin)FDA Link
10/2021 - 04/2006
4Sarcoglycans (beta Sarcoglycan)IBA
06/2020 - 05/2005
4Messenger RNA (mRNA)IBA
01/2020 - 11/2004
4BilirubinIBA
01/2019 - 01/2007

Therapy/Procedure

91Therapeutics
04/2024 - 05/2002
68Transplantation
04/2024 - 09/2005
64Heart-Assist Devices
02/2024 - 02/2002
40Heart Transplantation (Grafting, Heart)
01/2022 - 01/2003
28Coronary Artery Bypass (Coronary Artery Bypass Surgery)
12/2023 - 03/2002
24Transcatheter Aortic Valve Replacement
01/2023 - 09/2012
23Endovascular Aneurysm Repair
05/2023 - 08/2010
21Mitral Valve Annuloplasty
01/2023 - 04/2008
19Stents
01/2021 - 07/2005
17Cell- and Tissue-Based Therapy (Cell Therapy)
01/2023 - 02/2006
13Cardiopulmonary Bypass (Heart-Lung Bypass)
09/2017 - 01/2006
11Ligation
08/2023 - 12/2002
9Cell Transplantation
01/2023 - 01/2009
8Lung Transplantation
10/2016 - 11/2004
7Catheters
02/2024 - 09/2007
7Extracorporeal Membrane Oxygenation
12/2023 - 02/2006
6Renal Dialysis (Hemodialysis)
12/2022 - 02/2004
6Sternotomy
01/2021 - 10/2002
6Thoracotomy
01/2019 - 02/2004
6Operative Surgical Procedures
09/2017 - 09/2010
6Cardiomyoplasty
01/2013 - 05/2002
5Pneumonectomy (Lung Volume Reduction)
10/2020 - 06/2005
5Organ Transplantation
07/2017 - 01/2008
4Catheter Ablation
11/2021 - 07/2005
4Drug Therapy (Chemotherapy)
10/2020 - 08/2007
4Maze Procedure
01/2020 - 04/2010
4Sutures (Suture)
04/2019 - 09/2017